The purpose of this study was to examine the relations among teachers' personality characters based on the Big Five personality factors, stress coping strategies and psychological well-being. The data in this study were collected from 313 middle and high school teachers in Busan. The instruments used for the data collection were IPIP (International Personality Item Pool), The Ways of Coping Items, and psychological well-being scale each. T-test, correlation analysis, multiple regression analysis by using SPSS 12.0 program were applied to data processing The results of this research were summarized as follows :First, neuroticism(the subtype of the Big Five) of female teachers was higher than that of male teachers, however, openness(the subtype of the Big Five) of male was higher than female. Emotional alleviative coping(the subtype of stress coping strategies) and autonomy(the subtype of psychological well-being)of male was higher than female. Second, psychological well-being related to the life quality of teachers had a positive correlation with the Big Five personality factors such as extroversion, openness, affectiveness, conscientiousness but had a negative correlation with neuroticism. Third, psychological well-being showed a positive correlation with stress coping strategies factors such as problem-centered stress, social support stress coping but showed a negative correlation with emotion alleviative coping (the components of stress coping strategies). Finally, the Big Five personality factors(extroversion, openness, conscientiousness) showed a positive correlation with stress coping strategies. The Big Five personality factors such as extroversion, openness, affectiveness, conscientiousness had a positive correlation with stress coping strategies factors such as problem-centered stress, social support stress coping, wishful thinking stress coping. The Big Five personality factors(openness, affectiveness, conscientiousness) showed a negative correlation with stress coping strategies factor(emotion-centered stress coping). On the basis of the study results above, the life satisfaction and happiness of teachers is influenced by thought based on their own personality style and stress coping style about present problems. So this study will be of service to encourage that they live a meaningful career with satisfaction and accomplishment as a teachers and provide the basic information in developing program for them. Limitations of the current study and the suggestions for further research were offered.