Purpose: This study was to investigate the relationship self-esteem, quality of sleep and other factors on job stress. The participants were 108 new nurses are working on a hospital in seoul. Methods: A survey using a structured questionnaire was conducted with 108 new nursing students. The data was analyzed using PASW statistics 18.0 program. Results: The findings Factors affecting the job stress showed negative correlation with self esteem(r=-.269, p<.005), ajusted coping strategies(r=-.251, p<.001), and positive correlation with quality of sleep(r=.316, p<.001), malajusted coping strategies(r=587, p<.001). Multiple regression analysis, ajusted coping stratiges(p<.001), malajusted coping strategies(p<.001) was the dependent variable to increase the amount significantly higher affect job stress, these explanatory variables to explain the dependent variable job stress is 44.8%. Conclusion: The finding of this study suggest that it is necessary to develop an intervention program to prevent job stress and to cope with job stress reduction and prevention of new nurses. It also showed that adaptive stress method appropriate for individual was needed.