This study was conducted to analyze characteristics of the single subject research and the roadmap of the evidence-based practice based on the studied on vocabulary and reading instruction methods for students with Intellectual Disabilities. We analyzed the papers published from 2000 to June, 2014 in nine of academic journals registered with the Korea Research Foundation. The total number of collected theses was twenty four and we classified the road map according to quality indicators for evidence-based practice. and road map for evidence-based practice. This study was to provide various standards of selection that might be helpful in choosing a better scientific-based instruction method through understanding the characteristics of the theses, studied on vocabulary and reading instruction methods for students with intellectual disabilities, and so it is expected not only to increase the possibility of the field application for scientific-based instructors but also to be used as fundamental materials in on-site practical education. After analyzing the selected twenty four papers, theses were mainly using existing tools as measuring tools. In the analysis of the qualitative indicator, it achieved results satisfying the requirements of the qualitative indicator in participation object, variables, data collection and intervention program, however, it performed relatively low, in terms of evidence-based practice, for those might be important factors; observer reliability, internal validity and social validity. Additionally, the followings are the parts that turned out to have a lack of research. A detailed description for repeated study, securing stability by preparing data for proving the effectiveness, efforts to strengthen the effectiveness of intervention, practical use of various data analysis methods, inspection of the effectiveness of intervention period, strict controlling procedures and intervention environment, sufficient enough technical details for repeated studies in perspective of arbitrator. The results and limitations of this study, directions for future research, and implications were discussed.