Role of Endogenous Nitric Oxide in the Control of Salivary Secretion and Blood Flow. W onjae Kim， Sang Chae Nam\ and Miwon Kim1 Department of Oral Physiology & Institute of Dental Research， Chonnam National University Dental School and lDepartment of Physiology， Chonnam National Medical School， Kwan밍u501-190， Korea The present study was designed to investigate whether endogenous niπic oxide(EDNO) is involved in submandibular vasodilation and salivation induced by parasympathetic nerve stimulation. Effects of NW-nitro-Larginine- methyl ester (L-NAME) which blocks the synthesis of EDNO from L-arginine on the submandibular vasodilation and salivation induced by chorda stimu1ation or administration of various vasodilators were examined in anesthetized cats. Effect of L-NAME on K+ efflux induced by carbachol was also examined using the excised submandibular slice in vitro. In the submandibular slices， acetylcholine(lO 5 molfL) or vasoactive intestinal polypeptide(VIP， 10 5 molfL) increased N02 contents， which was prevented by pretreatment with L-NAME. Salivary secretion in response to the chorda stimulation(3 V， 1 msec， 1O