Severe cleft forms are associated with severe nasolabial deformities, and present a significant surgical challenge in order to achieve functional and aesthetic outcome. The aim of presurgical infant orthopedics (PSIO) is to reduce the severity of the cleft (e.g., nasal deformity, cleft size), thereby improving surgical results, reducing the need for lip and nose revisions. Since the concept of Presurgical infant orthopedics (PSIO) was first introduced by McNeil in 1950, various forms of orthopedic devices with different mechanics have been developed. The Latham device applies active force which align the maxillary segments and reduce the cleft size prior to definitive surgery. The Presurgical Nasoalveolar Molding (PNAM) device corrects the position of the nasal tip, alar base, philtrum, and columella improving nasal appearance, which can minimize the need for secondary nasal surgery. In this article we report sequential use of Latham device and Presurgical nasoalveolar molding (PNAM) device in unilateral complete cleft lip and palate patient