Our purpose of this study was to evaluate the association between depression, stress, and obesity indexes. Methods This study was performed in 110 healthy overweight and obese(BMI≥23 kg/m2) women in Korea. Subjects underwent abdominal CT(computed tomography) scanning and were asked to complete Beck depression inventory(BDI), social readjustment rating scale(SRRS), and stress response inventory(SRI) questionnaires. Weight, body-mass index(BMI), waist circumference(WC), and waist-hip ratio(WHR) were evaluated. Subjects were given written consent and this study was performed under permission of institutional review board of KyunHee University Hospital at Gangdong. Results 1. BDI and SRI were significantly correlated with VFA(visceral fat area)(p<0.05). However, other obesity indexes were not significantly correlated with BDI and SRI(p>0.05). 2. SRRS was not significantly correlated with all obesity indexes(p>0.05). Conclusions This study suggests that depression and stress might be correlated with visceral fat, and this result would be helpful for planning a treatment schedule of obese patients with depression or stress in the clinic.