INTRODUCTION CYTOKINE MARKERS AND PERIPHERAL INFLAMMATION IN BIPOLAR DISORDER INFLAMMATORY MEDIATORS AND THE CENTRAL NERVOUS SYSTEM INFLAMMATION AND CHANGES IN NEUROPLASTICITY NEUROENDOCRINE AND AUTONOMIC DYSREGLATION NEUROGLIOAL ABNORMALITIES ASTROGLIA FUNCTION AND GLUTAMATE ABNORMALITIES ANTI-INFLAMMATORY TREATMENTS-THE INFLAMMATORY PATHWAY ANTI-INFLAMMATORY POTENTIAL OF LITHIUM AND VALPROATE RE-PURPOSED DRUGS WITH ANTI-INFLAMMATORY PROPERTIES DEVELOPMENT OF BIOMARKERS-FOCUS ON CYTOKINES AND BDNF PERIPHERAL CYTOKINES IN BIPOLAR DISORDER SERUM BDNF AS A BIOMARKER FOR BIPOLAR DISORDER COMPARISON OF BIOMARKERS BETWEEN BIPOLAR DISORDER AND MAJOR DEPRESSIVE DISORDER p11 PROTEIN AND ITS RELATIONSHIP TO MOOD DISORDERS CONCLUSION REFERENCES