This paper examines the human enhancement claims of transnational humanism that apply advanced science and technology, especially NBIC to humans. Human enhancement has recently been philosophically controversial with the belief that technology can lead to the evolution of mankind. Philosophical and ethical problems related to human enhancement have been raised by various scholars in various perspectives. However, there are some scholars who still advocate human enhancement. Typically, Ingmar Persson & Julian Savulescu and Mark Walker argue that claims for technical human enhancement can be philosophically justified and we should be prepared for our use to make such enhancement in the future. This paper examines the claims of Persson & Savulescu and Walker, and examines the debates on moral engineering, focusing on Jotterand s criticism of it. And this paper examines the main issues presented in their debates in terms of neo-Confucianism. My approach is to criticize the position of moral engineering on the human nature and the essence of morality , the main themes that they have argued about, from the viewpoint of the Neo-Confucianism, and to find alternative views that can be presented at present.