The purpose of this study is to investigate the influence of music listening, vocalization with music listening, and break on chronic pain patients. Accordingly, this study tried to measure how much pain, mood, and autonomic nervous system were changed respectively. The subjects of study were chosen from chronic pain patients, who are under the care of a doctor at K university of hospital in seoul from January and May, 2008. The experiments were randomly assigned by researcher to investigate the effects of music listening, vocalization with music listening and break on chronic pain patients at an interval of one week. It is following that the results were taken through analyzing pre and post test data of SF-McGill pain Questionnaire, Prosecutor of Mood States and heart rate variable. First, the change of pain grade has the significant differences between break and vocalization with music listening. Second, the change of prosecutor of mood states has the significant differences between break and music listening, break and vocalization with music listening. Third, the change of autonomic nervous system has the significant differences between break and vocalization with music listening at its subarea: SDNN, stress resistance, and stress index. Fourth, both music listening and vocalization with music listening are of effective for the pain reduction. Music listening is of effective for mood states and vocalization with music listening is of effective for autonomic nerve system. key word : music listening, vocalization, pain, mood, autonomic nervous system.