Recently the researches to enhance the hand function of brain injured clients are increased. One of those aspects is related to in-hand manipluation. In-hand manipulation is divided to four types: that is finger-to-palm translation. palm-to-finger translation, shift, and rotation. The purpose of this study was to find type of in-hand manipulation in normal adults in six activities and to differentiate the pattern of in-hand manipulation between normal adults and children with cerebral palsy. The participants were consist of twenty normal adults and twenty cerebral palsy. children. As a results, cerebral palsy children significantly used at lower frequence than normal adults in 3 activities. Also, in the other items, there are some pattern to differenciate between normal adults and cerebral palsy children but that was not significant statistically. The development of in-hand manipulation skills involves improvement in the dimension of activities of daily living skills training and more detailed evaluation method will be needed.