Objective: The purpose of this study was to measure the level of stress of cerebral palsy wokers, and to investigate the relationship between the stress and stress inducing factors of cerebral palsy wokers in Korean manufacturing industry. Method: The sample used in this study consists of 66 employees with cerebral palsy. They are employees of the protective employment companies located in Seoul, Inchon and Gyung-gi province. The psycho-social well-being index (PWI), which was designed through modification of Goldberg’s 60-items of General health Questionaire (GHS), was used to measure the stress level. The independent variables are general and disability characteristics, workplace-related characteristics. The collected data were analyzed using SAS version 6.12 program. Results: The results of this study were summarized as follows : The average score for the level of stress response was 55.19 (±19.17). The high risk group was 32% of the woker with cerebral palsy, the latent stress group was 62%, and healthy group was 6%. The overall stress level was very high. The level of stress was significantly higher in respondents who has poor self-perceived health status, who can not satisfied with their job and workplace. Conclusions: In conclusion, the result of this study suggest that appropriate prevocational programs, should be estabilish and provided for reducing the stress of cerebral palsy wokers.