Objective: The purpose of this study is to develop an evidence-based occupational therapy guideline for Alzheimer’s disease based on the Occupational Therapy Practice Framework in order for occupational therapists to choose appropriate evaluations and interventions and provide effective, economical, and professional services to patients with Alzheime\r’s disease and their caregivers. Methods: 5 occupational therapy guidelines evaluated with the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool. In order to identify additional evidence on occupational therapy conducted in Korea, conduct a literature review and found 185 articles. Of these, 58 articles on occupational therapy evaluation and intervention were selected and analyzed. Results: The final guideline was completed by combining the first draft and the items obtained through additional literature review based on the Occupational Therapy Practice Framework. The items were combined into domains of area of occupation, performance skills, performance patterns, environment, activity demands, and caregivers. ADL, IDL, cognitive skill, behavioral management, training of physical function, physical environment, and care-giver domains had high recommendation grades (A). Conclusion: Studies with high levels of evidence have been conducted on various intervention methods, thereby confirming the effectiveness of occupational therapy. Moreover, this study suggest grades of recommendation in order for effective approaches to be taken in each domain.