Purpose: Breast cancer survivors(BCS) have memory, attention, processing speed, and/or executive function impairment affecting their quality of life(QOL) and function. Study aims were: (1) compare computer-assisted cognitive training with visual exercises to one with audio+ visual exercises, and (2) gain insight into the relationship between engagement in meaningful activities, cognitive deficits and QOL. Methods: This pilot study used an experimental design with 24 women. Pre and post measures assessed working memory, perceived cognition, QOL and engagement in meaningful activities. Results: Treatment effects were not significant for working memory or engagement in meaningful activities. Visual group participants scored significantly better on perceived cognitive function posttest test(M = 91.62, SD = 21.75) than pretest(M = 74.48, SD = 29.00), p = .010 and significantly higher on QOL posttest(M = 6.42, SD = 1.27) than pretest(M = 5.60, SD = 1.76), p = .004. Pretest perceived cognitive function was significantly associated with pretest(ρ = .617, p < .001) and posttest(ρ = .436, p < .05) QOL. Conclusion: Computer-assisted cognitive training with visual exercises appears to improve perceived cognitive function and QOL for BCS. A positive relationship exists between perceived cognitive function and QOL.