Objectives: This systematic review examined the association of animal-assisted interventions (AAI) with quality of life (QoL) for pediatric oncology patients, for potential use in occupational therapy practice. Methods: Articles published in peer-reviewed journals between 2002-2019 from PubMed, MEDLINE, CINAHL, American Journal of Occupational Therapy (AJOT), Journal of Oncology, SCOPUS, and OTSeeker were selected for AAI with therapy dogs specific to the target population of pediatric oncology patients undergoing treatment in clinical settings. Results: Moderate evidence was found for AAI and mood improvement, pain reduction, and stress relief; and low-level evidence supported AAI for decreasing anxiety. The most significant AAI improvements were seen in perceptions of pain, stress levels, and mood. Discussion: Evidence suggests that occupational therapists may want to consider incorporating AAI into therapy sessions as it serves as a distraction and short-term coping strategy for children undergoing oncological treatment.