The Fourth Industrial Revolution is unfolding and posing great impact on education. To keep pace with social development, education must take initiation for reform in the first place, so that a society-tailored future generation could be delivered through education. In the background of the Fourth Industrial Revolution, this paper first summarized the features and impacts of the new industrial revolution and on the basis of China’s college education reality, proposed a new reform paradigm for China’s college education in the era of the Fourth Industrial Revolution in five aspects: firstly, the college education goal should be changed to cultivate inter-disciplinary, applicative, innovative talents and these talents also need to be equipped with global citizenship awareness; secondly, to match the education goal a diversified curriculum is suggested, including foundational, major, blended and individualized course; thirdly, new teaching and learning models have to be pursued, and the teaching process should be transformed to the student centered; fourthly, a quality oriented need to be considered, and in the same vein the evaluation of students’ life-long learning abilities should be taken into account as well; lastly, a platform based administration system are proposed to better tailor China’s current college education reform.