The increasing cross-national movements of people today leads to rising racial, ethnic, linguistic, and cultural diversity in classrooms. Yet, a vast majority of teachers do not know how to interact effectively with students from varying backgrounds. Scholars argue that teachers in a diverse classroom need additional skills and abilities like culturally responsive teaching skills. Such skills and abilities help teachers meet the needs of both immigrant and native-born students. However, there are not many empirical studies that investigate the effects of professional development for teachers in a diverse classroom. Thus, this study investigates the effects of professional development. Data for the study are taken from the OECD’s Programme for International Student Assessment sample of 177 schools, 3,680 teachers, and 5,712 students from the U.S. Relying on a series of OLS regression analyses, this study estimates the effects of professional development for teachers in a multicultural
setting. The results suggest that in-service teacher professional development may have some positive effect on the immigrant students’ achievement in mathematics and science, while the effects on the native students’ achievement remain insignificant.