The objective of this study is to explore the structural relationships among job satisfaction, leisure activities, self-esteem, and acceptance of disability for persons with visual impairment. In addition, the role of self-esteem in the relation between job satisfaction, leisure participation and acceptance of disability were investigated. In doing so, this study used the first dataset from 2nd Wave data extracted from the Panel Survey Employment for the Disabled (PSED) collected by the Employment Development Institute (EDI). A total of 330 respondents who report visual impairment as a major disability and are currently working were utilized for the analysis. The results showed that job satisfaction experienced by the visually impaired had a direct impact on the acceptance of disability and indirectly through self-esteem. Participation in leisure activities of the visually impaired did not directly affect the acceptance of disability, but it was indirectly influenced by self-esteem. Based on these findings, practical implications in the field of work and leisure to increase the acceptance of disability for persons with visual impairment were discussed.