Cleft lip and palate is one of the most common craniofacial deformities that have physical and psychological influences on patients’ lives. In 1950, the concept of presurgical infant orthopedics (PSIO) was introduced because surgery alone can be aggressive and less controlled treatment in patients with wide cleft or severely protruded premaxilla. Latham appliance is a kind of PSIO which can make an active forces for alignment and approximation of alveolar segments. The newborn with bilateral complete cleft lip and palate was referred from the department of Neonatology to the department of Oral & Maxillofacial Surgery (OMFS) for evaluation and further treatment. The Latham appliance was applied 10 weeks after birth and activated for 1 month. After the resting period, the operation of primary lip and nose repair was performed with removal of the Latham appliance at 6 months after birth. Through the activation of the Latham appliance, minimizing the scar tissue and reducing tension was possible, and a successful result in esthetics and function can be made.