This study was performed to investigate any connections between self-esteem, professional self-concept, and communication competence among second-year Korean nursing students. From March 4th to 8th, 2019, self-reporting questionnaires were employed to collect data from 233 second-year nursing students in C college located in South Korea. The data were then analyzed by a SPSS WIN 25.0 program using descriptive statistics, t-test, ANOVA, and Pearson’s correlation coefficient. The participants’ mean score for self-esteem, professional self-concept, and communication competence were 3.12 (±0.42), 3.11 (±0.33), and 3.34 (±0.44), respectively. The study uncovered significant differences in the subjects’ ability to adapt to changing circumstances or environments (p<0.00) and their satisfaction with a nursing major (p<0.011) depending on the subjects’ general characteristics. The study also found significant (p<0.001) correlations among self-esteem, professional self-concept, and communication competence. The analysis showed that these variables had significant positive correlation with the ability to adapt to changing circumstances or environments and satisfaction with a nursing major and college life. Via self-assessment, the nursing students scored an average of 7.44 on communication ability. The study discovered a statistically significant positive correlation between the nursing students’ communication ability and self-esteem (r=0.525, p<0.01), professional self-concept (r=0.399, p<0.01), and communication competence (r=0.531, p<0.01). According to the results of this study, there is a need to develop a program targeting second-year nursing students to help them build professional nursing values before they start their clinical training.