Purpose: This study was done to identify factors influencing the quality of life (QOL) of cancer patients hospitalized in long-term care hospitals (LCH), particularly those offering complementary alternative therapies (CAT). Methods: Participants were 115 cancer patients hospitalized in cancer-specialized LCHs in Gyeongsangbuk-do. Data collection was done using the following scales: Functional Assessment Cancer Therapy-General (FACT-G), Satisfaction of LCH Questionnaire modified by researchers, Usage and Satisfaction of CAT Questionnaire developed by researchers, M.D. Anderson Symptom Inventory-Korean (MDASI-K), Self Care Activity Tool, and Multi-dimensional Scale of Perceived Social Support (MSPSS). Step-wise multiple regression was used to identify factors influencing the quality of life of cancer patients in LCHs. Results: The factors identified as influencing the QOL of cancer patients hospitalized in LCH were physical symptoms (β=-.41, p<.001), satisfaction with exercise therapy in CAT (β=.27, p<.001), social support (β=.24, p<.001), satisfaction with LCH (β=-.19, p=.006), and male gender (β=-.16, p=.023) with an explanatory power of 49.0%(F=22.73, p<.001). Conclusion: The LCHs should strive to improve the QOL of cancer patients by enhancing physical symptom care, strengthening exercise therapy in CAT, and improving social support and satisfaction with the hospital.