The purpose of this study is to verify the effectiveness of Transactional Analysis group program to improve the self-esteem and interpersonal relationship of alcoholics. Subjects hoping to solve the problems of themselves were selected by preliminary counseling and were analyzed 120minutes over 10 sessions on a weekly basis from July 22 to September 30, 2019. The experimental group was composed of 10 people, and the control group was composed of 10 people not participating in the program. In order to verify the effectiveness of the alcoholic’s Transactional Analysis group program, a single control group was measured before and after, and the primary results of this study is as following. First, self-esteem has changed in a positive direction for the self-esteem of the experimental groups participating in the Transactional Analysis group program. Second, through the Transaction Analysis group program, the level of openness was significantly improved in the formation of interpersonal relationships among alcoholics. Finally, as a result of qualitative analysis of the change in the self-state of alcoholics, positive change and growth of the self-state appeared due to self-awareness and proper distribution of psychological energy utilization in interaction with others. Based on the results of the study, the Transactional Analysis group program contributed to the self-esteem and improvement of interpersonal relationships among alcoholics and suggested future research directions.