Particulate matter research is of great significance in solving atmospheric environment problems. The heterogeneous reaction of mixed gas on different mineral oxides and coal ash was studied based on a laboratory-built aerosol generating reactor. The product formed on particles was investigated by ion chromatography (IC). SO2 and NO2 could react on oxides to form secondary particles and the order of reactivity of mineral oxides under laboratory reaction conditions is: Al2O3>MgO>CaO>>SiO2, Fe2O3. NO2 has a synergistic effect on the heterogeneous reaction of SO2 on Al2O3 in the presence of O2. The synergistic effect of SO2 and NO2 on Al2O3 is further enhanced in the case of high relative humidity (RH) and in the presence of NH3. The reaction on Al2O3 under different gas concentration ratios is compared, and it is identified that SO2 and NO2 concentrations make an effect on aerosol production. The heterogeneous reactions of SO2 and NO2 on various coal ash are different. The order of reactivity of the three coal ashes is WH>MHU>Centennial. The secondary particulate matter formed on coal ash is higher than that on single metal oxide.