This study is an experimental research designed to determine the effects of song-focused music therapy program based on positive psychology on subjective well-being and optimism of migrant women from multi-cultural families. The subject under the research was 58 participants in the ‘J’ and ‘I’ areas. It was made up of 28 experimental and 30 control group. The musical intervention period consisted of a total of 12 sessions, twice a week from August 6th to September 17th 2018. Intervention had been conducted to the experimental group only. To prove statistically significant differences between two groups, the scores of ‘subjective well-being’ and ‘optimism’ were measure before and after the program and then analysed by SPSS for Windows 23. To measure the effects, PANAS, SWLS and LOT-R were used. Homogeneity between two groups is verified through the independent sample t-test. The result of this study is as follows. First, there was a significant difference between two groups in subjective well-being score consist of positive affect, negative affect and satisfaction with life. Second, there was a meaningful difference between ex ante and ex post subjective well-being scores in the experimental group. While the positive affect and the satisfaction with life were improved, the negative affect diminished. Third, there was a significant difference between the two groups in the optimism level. Finally, there was a meaningful difference between ex ante and ex post optimism level in the experimental group. Thus, it confirmed the positive effects of song-focused music therapy program based on positive psychology on subjective well-being and optimism of migrant women from multi-cultural families, and it proposes development and application of music therapy program based on positive psychology.