The purpose of this study was to analyze quantitative studies regarding the effect of music therapy program on hospice and palliative patients and provide a basis for more effective application in music therapy in hospice palliative care. A meta-analysis was conducted on 31 studies including domestic and international studies. The results of the study are as follows: First, the overall mean effect size was –0.579, which means a medium effect size according to Cohen’s interpretation criteria. Second, music therapy has a positive effect on physiological and psychological symptoms of hospice and palliative care patients. Third, recorded music therapy is more effective than live music or mixed music. Fourth, a total of 6 to 10 sessions were the most effective. Fifth, 20minutes is the most adequate as a session length. Sixth, when the patients engage in music therapy receptively, music therapy could be more helpful. Lastly, out-patient hospice service would increase the effect of music therapy. The above results show that music therapy can have a positive effect on hospice and palliative care patients and positively affect them.