The purpose of this study is to examine whether anger-in and anger-out mediate the effects of socially prescribed perfectionism on student adaptation to college. The subjects of this study were collected from three Universities in Seoul and Gyeonggi-do. A total of 499 college students participated in this study voluntarily. Of these, 54 of the participants were excluded due to insufficient responses or non-responses. Thus, a total of 445 college students’ data was collected in this study. Multidimensional Perfectionism Scale (HMPS), State-Trait Anger Expression Inventory Korean version (STAXI-K), and Student Adjustment to College Questionnaire (SACQ) was completed, and SPSS 21.0 was used to analyze the data. The results of the study are as follows. First, anger-in mediated the effects of socially prescribed perfectionism on student adaptation to college. Second, anger-out mediated the effects of socially prescribed perfectionism on student adaptation to college. The present study verified that the focus of socially-prescribed perfectionism has negative roles. In the effects of socially-prescribed perfectionism on student adaptation to college, anger-in and anger-out showed mediation effects. Based on these results, it is expected that this research provides a foundation for the development of education, counseling, and treatment programs for college life adaptation.