Purpose: The purpose of this study was to identify the factors influencing nurses’ caring behavior. Methods: The descriptive study included 178 intensive care unit (ICU) nurses who completed a self-report structured questionnaire. The data were analyzed using descriptive statistics, independent t-test, one-way ANOVA, and Pearson’s correlation and multiple regression analysis using the IBM SPSS/WIN 23.0 program. Results: Significant correlation existed between perception of Patient- and Family-Centered Care (PFCC) and nurses’ caring behaviors (r = .36, p< .001). Multiple regression analysis showed that perception of support (β= .36, p< .001), total career length (β= .33, p< .001), and familiarity with PFCC (β= .15, p= .018) affected the caring behavior of ICU nurses. These variables explained 30.0% of the variance in caring behavior. Conclusion: Effective strategies are needed to improve perceptions of support as well as to promote PFCC for increasig the frequency of caring behavior among ICU nurses.