Purpose: The purpose of this study was to investigate the factors influencing osteoporosis awareness depending on the family structure in postmenopausal women aged over 50 years with osteoporosis. Methods: The study was a cross-sectional study that used secondary data. Postmenopausal women with osteoporosis aged over 50 years (n=567) from the National Health Nutrition Survey of the 5th (2010, 2011) were selected for analysis. Data were analyzed by complex sampling design multiple regression analysis. Results: Among the patients with osteoporosis, the osteoporosis awareness was very low at 29.0%, and 32.5% for single households and 28.1% for household with spouses. There were significant differences in the factors influencing osteoporosis awareness depending on the family structure. For single household, factors that influenced osteoporosis awareness included sleeping for more than 9 hours (OR, 4.32), anxiety and depression (OR, 3.21), a history of fracture (OR, 0.29), and a family history of osteoporosis (OR, 0.29). In the household with a spouse, osteoporosis awareness was highest in women in their 60 seconds (OR, 3.45), unhealthy group (OR, 2.27), and underweight group (OR, 5.31). Other factors that influenced osteoporosis awareness included pain/discomfort (OR, 2.31), smoking (OR, 7.71), and a history of fracture (OR, 0.36). Conclusion: It is necessary to improve osteoporosis awareness for effective osteoporosis management through osteoporosis screening and counseling, and continuous osteoporosis education programs.