Purpose: This study investigated the effect of pressure injury nursing knowledge, and pressure injury nursing attitudes, on pressure injury nursing practice. Methods: Participants in this descriptive study were 141 nurses at 20 geriatric hospitals. Data was collected August 24, 2021- April 4, 2022, and analyzed in terms of Independent t-test and one-way ANOVA, Scheffé test, Pearson’s correlation coefficient, and multiple regression, using the SPSS/WIN 27.0 program. Results: Pressure injury nursing practice positively correlated with pressure injury nursing attitudes (r=.44, p<.001). Factors influencing pressure injury nursing practice were pressure injury nursing attitudes (β=.43, p<.001), and gender (β=.21, p=.006). The model used in this study explains 22.8% of pressure injury nursing practice (Adjusted R2=22.8, F=11.30, p<.001). Conclusion: Results show factors that influence pressure injury nursing practice of nurses in geriatric hospitals. Based on the results, pressure injury nursing practice programs must include factors that improve pressure injury nursing attitudes. A follow-up study to confirm the impact of developing a program for increasing pressure injury nursing practice is also recommended.