The purpose of this study is to search the effects of human-centered art therapy on depression and self-esteem of early adult women who experienced childhood trauma. The subject of the study is a 23-year-old unmarried women who shows depression, anxiety, anger, worthlessness, helplessness, and low self-esteem because of continuously and repeatedly experiencing childhood trauma. The study was conducted a total of 21 sessions once a week, 60 or 120 minutes, excluding the initial interview, pre-test, post-test, and follow-up test from March to November 2021. In Each session unstructured art therapy and expression suitable for the provided situation were conducted. The measurement tool compared and analyzed quantitative and qualitative changes using the K-BDI-Ⅱ, SEI, K-HTP, and KFD, and confirmed qualitative changes by session of individual art therapy. According to the research results, human-centered art therapy had a positive effect on reducing depression and improving self-esteem in early adult women who experienced negative emotions through childhood trauma and failed to adapt to their first work life as adults. Based on the above, the significance and limitations of this study were discussed.