The use of doping has had a long history in sports. Doping is becoming a more importantissue nowadays, especially in professional sport leagues. Because of commercialization of sports,sports for winning sake, and development of science and technology, players in theprofessional leagues are always facing pressure to stay on top and fall into temptation of theuse of performance-enhancing drugs. The use of drugs in sport is definitely considered asdeviant behavior among the players as well as one of the major current issues in sport teamsand their leagues. Therefore, it is highly required to have legal device and institutionalstrategies/policies in the professional leagues in order to do advanced prevention. Professionalsports leagues should realize that performance-enhancing drugs use among their players canlead to start losing their fans and eventually destruction of the leagues. Since 2008, professional sports leagues in South Korea such as Korean BaseballOrganization (KBO), Korean Basketball League (KBL), and Korean Football League(K-League) started to seriously take action against doping by forming their own drugs-relatedpolicies and rules. In the current study, we want to examine potential legal issues andinstitutional matters from policies established in those Korean professional leagues. At thesame time, we will also look over the Big Four American professional sports leagues’ (i.e.,Major League Baseball, National Football League, National Basketball League, and NationalHockey League) anti-doping rules and policies. By comparisons of policies, we would like tosuggest some improvement points and the direction for future anti-doping policy to theKorean professional sports leagues and their stakeholders.