The purpose of this study is to understand the life and situation of the male ministers working for campus mission organizations by diagnosing the stresses experienced by them and identifying the process of their adapting to stresses, to determine methods to help them based on the outcome of this research. For this purpose, 12 male ministers working for two different college missionary groups were selected: 2 in their 20s, 4 in their 30s, and 6 in their 40s; 8 are married and 4 are singles. A grounded theory approach was employed for the analysis of the in–depth interviews conducted. Empirical phenomena of stresses are negative emotion, downturn in the ministry, relational conflicts, and spiritual depression, and the types of adjustment process are classified into isolation type, problem–solving type, relationship–pursuing type, spirit–pursuing type, and growth–oriented type. Theological reflection was attempted based on the outcome of the study through systematic pastoral theological methodology. Also, personal care, supporting care, and cultural care were suggested while emphasizing the needs for systematic care for male ‘ministers’.