In this descriptive correlation study, the focus was on the effects of physical ability, depression and social support on quality of life. The participants were 142 people, 65 years of age or over with low incomes. Convenience sampling was used. Data were analyzed with descriptive statistics, t-test, ANOVA. Pearson correlation coefficient, and stepwise multiple regression using the SPSS PC+ program. Quality of life scores identified statistical significant differences for gender, education, marriage status, leisure activity, perceived health status, hospitalization in the past year and sleep status. Quality of life scores correlated negatively with depression scores and positively with IADL. physical fitness, ADL and spouse support. Variables significantly influencing quality of life were depression, IADL. sleep status, physical fitness, ADL, spouse support, and leisure activity. These variables explained 67.7% of the variance in quality of life. In conclusion, factors identified as affecting quality of life were depression, IADL, sleep status, physical fitness, ADL, spouse support and leisure activity. Nursing intervention programs developed to reduce depression in elders should include physical fitness, ADL, spouse support, and leisure activity. These factors must be assessed when planning nursing interventions to reduce depression and improve quality of life in elders at home.