This study aimed to evaluate the effect of 12 week regular aerobic exercise on IL-6, CRP, immunoglobulin in middle-aged obese women The subjects of this study were totally 20 (10 in the normal group, 10 in the obesity group). The subjects was provided with 3 tines IE week of participation in walking exercise for 12 week periods each of which was taken 45 minutes. They were assessed for the IL-6, CRP, 19A, IgG, IgM throughout pre, middle, post testing in both group. The collected data were analyzed by Two-way mixed ANOVA The result indicated that. The fact of CRP were decreased throughout pre, middle, post testing in the normal & obesity group. but It was no significant difference. The fact of 19A, IgG, IgM were no significant difference in the groups, but It was significant difference in the times Consequently, this research is considered to suggest a new possibility of improving the immunoglobulin of obese women through aerobic exercise.