This morphological study was carried out to investigate the healing effect of open and occlusive dressing on rabbit skin wounds. The male white rabbits were given incisional wound measuring 1.0cm in length and excisional wound measuring 1.0×0.2cm respectively on backs. Five rabbits among them received sterilization with betadine twice a day and kept wound open. Another group of rabbits received sterilization and occlusive dressing with application of 1% sulfadiazine ointment and covering of gauze. The rabbits were observed at 5, 10, and 15 days after dressing with light microscope. The results were as follows.
Both incisional and excisional wounds received open and occlusive dressing respectively revealed formation of scab and regeneration of epidermal epithelial cells at wound margin. The superficial dermis showed infilatration of neutrophils, monocytes, and lymphocytes, fibroblastic proliferation, and edema. On 10 days after open and occlusive dressing the scab had disappeared and regeneration of epidermal epithelium was completed. The capillaries and inflammatory cells were decreased in number. However, edema and fibroblastic proliferation were more pronounced. On 15 days after open and occlusive dressing, there were keratinization of regenerated epidermal epithelium, loss of inflammatory infiltration, edema, and capillary proliferation, and increase of fibroblastic proliferation and collagen fibers. The amount of scars were less in incisional wound than of excisional one. There were no differences in healing processes between both dressing methods.
According to the above results, it was conceived that sterilization of wound is more important in wound healing than dressing method in trivial wounds.