An extensive effort is being made to innovate education throughout the world as so-called information society approaches. Innovation of college education in Korea, not an exception, should entail moving to a new form which is completely different from now as envisioning the coming century. Nonetheless, lecture method, as an instance, is being uniformly used in higher education even in the situation where laboratory practice is required. This study, in this vein, explored a way to utilize individualized instruction as a viable alternative to the predominant lecture method in college teaching. Specifically, the objectives were to : (a) develop an individualized instructional system which would be used in a college course though a semester, and (b) provide ground data in employing the individualized instruction as an innovation by analyzing influences of aptitude variables of students facilitating the effectiveness of it. Majoring in education at Y university in Seoul and taking a instructional media course, forty three(18 males and 24 females) subjects participated in this study. Participants were randomly assigned to one of two treatments, received their respective instruction, in-class group instruction and independent study. All subjects completed four individual criterion test measuring different learning objectives. The results indicate that independent study may be employed as a alternative form of college instruction but the influences of students' aptitude variables facilitating the effectiveness of it could not be comprehensively seized. This fact, instead, implies that independent study may be a useful way of teaching in higher education which reduces individual differences regarding these aptitude variables. Also, it was found that college student's GPA may be a major variable influencing the academic achievement regardless of instructional methods.