This article aims to pursuit the process of settlement, growth, development and industrialization of French pharmaceutical manufacture, which was in a backward state. In this respect, first of all, we analyzed the problem of Germinal law in the early nineteenth century that set up a stepping-stone for industrialization for the future. Then, we studied power struggle between officines and laboratories. Finally, the crucial factors of French pharmaceutical industrialization were discussed. With these works, the understanding of pharmaceutical history in France can be regarded as meaningful work that enables the trial of graft between industrial history and history of science. By overcoming the contradiction of regulation and ambiguity of Germinal law, the early pharmaceutical companies created the enterprises at a superior scale while they were using capital and production method intensively. In the late nineteenth century, pharmaceutical enterprises heightened the competitive power. Most officines were stagnant, and finally settled down into the simple pharmacy system of these days due to three factors as follows: science-based production method, sp?cialit?’s appearance and new advertising device, and the development of pharmaceutical technic that demands the mass production system. Although there existed discord and conflicts between officines and laboratories in this process, they pertinently stitched the problems up. By meeting the expectation of those days, French pharmaceutical enterprises accomplished industrialization and have finally gotten off the ground since 1920s.