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어머니와 교사가 보고한 유아기 외현화 문제행동의 발달경로에 미치는 기질의 영향
한국교육치료학회 교육치료연구 2016, Vol.8 No.2 9 291-310 (20 pages)
본 연구에서는 어머니와 교사의 반복 평가를 통해 유아기 외현화 문제행동 발달경로의 형태를 확인 하고, 이에 영향을 주는 유아 기질의 영향력을 검증하고자 하였다. 연구대상은 경기도에 거주하는 유아 165명이었다. 동시대집단 시계열설계를 적용하여 잠재성장곡선분석을 실시한 결과 첫째, 어머 니와 교사 모두 외현화 문제행동에 대해서는 선형적으로 감소하는 발달경로를 보고하였으나, 변화 율의 개인차는 어머니 보고 자료에서만 유의미하였다. 둘째, 외현화 문제행동 발달경로의 초기치에 영향을 주는 요인에 대해서 어머니 보고... -
Effects on G2/M Phase Cell Cycle Distribution and Aneuploidy Formation of Exposure to a 60 Hz Electromagnetic Field in Combination with Ionizing Radiation or Hydrogen Peroxide in L132 Nontumorigenic Human Lung Epithelial Cells
HeeJin, HyeEunYoon, Jae-SeonLee, Jae-KyungKim, SungHoMyung, Yun-SilLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.2 6 119-124 (6 pages)
The aim of the present study was to assess whether exposure to the combination of an extremely low frequency magnetic field (ELF-MF; 60 Hz, 1 mT or 2 mT) with a stress factor, such as ionizing radiation (IR) or H2O2, results in genomic instability in non-tumorigenic human lung epithelial L132 cells. To this end, the percentages of G2/M-arrested cells and aneuploid cells were examined. Exposure to 0.5 Gy IR or 0.05 mM H2O2 for 9 h resulted in the highest levels of aneuploidy; however, no cells... -
(-)-Epigallocatechin-3-gallate Modulates the Differential Expression of Survivin Splice Variants and Protects Spermatogenesis During Testicular Torsion
NadaAl-Ajmi, MayAl-Maghrebi, WaleedMohammedRenno 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 2 259-265 (7 pages)
of apoptosis induction. Histological analyses revealed increased DNA fragmentation and increased damage to spermatogenesis associated with decreased seminiferous tubular diameter and decreased germinal epithelial cell thickness in the TT/D+vehicle group. These changes were reversed to almost sham levels upon EGCG treatment. Our data indicate that EGCG protects the testis from TT/D-induced damage by protecting the morphology of the seminiferous tubules and modulating survivin 140 expression. -
Differential Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on Motor Behavior and Dopamine Levels at Brain Regions in Three Different Mouse Strains
Keun-SungLee, Jin-KooLee, Hyung-GunKim, HakRimKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.1 13 89-97 (9 pages)
Developing an animal model for a specific disease is very important in the understanding of the underlying mechanism of the disease and allows testing of newly developed new drugs before human application. However, which of the plethora of experimental animal species to use in model development can be perplexing. Administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a very well known method to induce the symptoms of Parkinson's disease in mice. But, there is very limited... -
TRPM7 Is Essential for RANKL-Induced Osteoclastogenesis
Yu-MiYang, Hwi-HoonJung, SungJunLee, Hyung-JunChoi, MinSeukKim, DongMinShin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.1 10 65-71 (7 pages)
The transient receptor potential melastatin type 7 (TRPM7) channel is a widely expressed non- selective cation channel with fusion to the C-terminal alpha kinase domain and regarded as a key regulator of whole body Mg2+ homeostasis in mammals. However, the roles of TRPM7 during osteoclastogenesis in RAW264.7 cells and bone marrow-derived monocyte/macrophage precursor cells (BMMs) are not clear. In the present study, we investigate the roles of TRPM7 in osteoclastogenesis using methods of small... -
Dexamethasone Induces FcgRIIb Expression in RBL-2H3 Cells
PrashantaSilwal, Mi-NamLee, Choong-JaeLee, Jang-HeeHong, UkNamgung, Zee-WonLee, JinhyunKim, KyuLim, GiRyangKweon, JongILPark, SeungKielPar 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 4 393-398 (6 pages)
levels potently, while FcՅRI and FcՃRIIb were minimally affected. Next, we examined expressions of the Fc receptors on cell surfaces by the flow cytometric method. Only FcՃRIIb protein expression was significantly enhanced by Dex treatment, while FcՃRI, FcՃRIII and FcՅRI expression levels were marginally changed. Our data showed, for the first time, that Dex regulates Fc receptor expressions resulting in augmentation of the inhibitory receptor FcՃRIIb. -
The Protective Effect of Black Ginseng Against Transient Focal Ischemia-induced Neuronal Damage in Rats
Hyun-JungPark, HyunSooShim, KyungSooKim, InsopShim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.6 3 333-338 (6 pages)
Black ginseng (BG) has been widely used as herbal treatment for improving physiological function. In order to investigate the neuroprotective action of this herbal medicine, we examined the influence of BG on the learning and memory of rats using the Morris water maze, and we studied the effects of BG on the central cholinergic system and neural nitric oxide synthesis in the hippocampus of rats with neuronal and cognitive impairment. After middle cerebral artery occlusion was applied for 2h, the... -
GS28 Protects Neuronal Cell Death Induced by Hydrogen Peroxide under Glutathione-Depleted Condition
HwaOkLee, YuJeongByun, Kyung-OkCho, SeongYunKim, Seong-BeomLee, Ho-ShikKim, Oh-JooKwon, Seong-WhanJeong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.3 5 149-156 (8 pages)
necrostatin-1 completely inhibited H2O2-induced cytotoxicity, ROS generation, and p38 activation, indicating that the cell death is necroptotic. Collectively these data imply that H2O2 induces necroptotic cell death in the GS28 siRNA-transfected cells and that the necroptotic signals are mediated by sequential activations in RIP1/p38/ROS. Taken together, these results indicate that GS28 has a protective role in H2O2-induced necroptosis via inhibition of p38 MAPK in GSH-depleted neuronal cells. -
Effects of Erythropoietin on Memory Deficits and Brain Oxidative Stress in the Mouse Models of Dementia
RohitKumar, AmteshwarSinghJaggi, NirmalSingh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.5 15 345-352 (8 pages)
The present study was undertaken to explore the potential of erythropoietin in memory deficits of mice. Memory impairment was produced by scopolamine (0.5 mg/kg, i.p.) and intracerebroventricular streptozotocin (i.c.v STZ, 3 mg/kg, 10Ռl, 1st and 3rd day) in separate groups of animals. Morris water- maze test was employed to assess learning and memory. The levels of brain thio-barbituric acid reactive species (TBARS) and reduced glutathione (GSH) were estimated to assess degree of oxidative... -
Protein Kinase C-mediated Neuroprotective Action of (-)-epigallocatechin-3-gallate against Aβ1-42-induced Apoptotic Cell Death in SH-SY5Y Neuroblastoma Cells
SujeongJang, KyoungWanYou, Song-HeeKim, SungJunPark, Han-SeongJeong, Jong-SeongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.5 1 163-169 (7 pages)
The neurotoxicity of amyloid β (Aβ) is associated with an increased production of reactive oxygen species and apoptosis, and it has been implicated in the development of Alzheimer's disease. While (-)-epigallocatechin-3-gallate (EGCG) suppresses Aβ-induced apoptosis, the mechanisms underlying this process have yet to be completely clarified. This study was designed to investigate whether EGCG plays a neuroprotective role by activating cell survival system such as protein kinase C (PKC),...


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