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Proteomic Analysis and the Antimetastatic Effect of N-(4methyl)phenyl-O-(4-methoxy) phenyl-thionocarbamate-Induced Apoptosis in Human Melanoma SK-MEL-28 cells
Choi. Su-La, Choi. Yun-Sil, Kim. Young-Kwan, Sung. Nack-Do, Kho. Chang-Won, Park. Byong-Chul, Kim. Eun-Mi, Lee. Jung-Hyung, Kim. Kyung-M 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 11 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2006, Vol.29 No.3 224-234 (11 pages)
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Effect of fermented soybean products intake on the overall immune safety and function in mice
Jae Hee Lee, Se Hee Paek, Hye Won Shin, Seung Yeon Lee, Byoung Seok Moon, Jung Eun Park, Gyeong Dong Lim, Chang Yul Kim, Yong He 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 1호 4 25-32 (8 pages)
Various functional activities have been reported for the fermented soybean products doenjang (DJ) and cheonggukjang (CGJ), although no systemic investigations of their immune functions have been conducted to date. We examined the effects of an experimental diet of DJ, CGJ, or a mixture of unfermented raw material for 4 weeks on overall immunity and immune safety in mice. No significant alterations were observed in peripheral or splenic immune cells among groups. Enhanced splenic natural killer... -
Genistein attenuates isoflurane-induced neurotoxicity and improves impaired spatial learning and memory by regulating cAMP/CREB and BDNF-TrkB-PI3K/Akt signaling
TaoJiang, Xiu-qinWang, ChuanDing, Xue-lianDu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 2 579-589 (11 pages)
plant-derived isoflavone, has been shown to exhibit neuroprotective effects. The present study was performed to examine the protective effect of genistein against isoflurane-induced neurotoxicity in rats. Neonatal rats were exposed to isoflurane (0.75%, 6 hours) on postnatal day 7 (P7). Separate groups of rat pups were orally administered genistein at doses of 20, 40, or 80 mg/kg body weight from P3 to P15 and then exposed to isoflurane anesthesia on P7. Neuronal apoptosis was detected by TUNEL... -
Multiple Effects of a Novel Epothilone Analog on Cellular Processes and Signaling Pathways Regulated by Rac1 GTPase in the Human Breast Cancer Cells
HongZhang, FanAn, LiTang, RongguoQiu 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.2 4 109-120 (12 pages)
synergy between Rac1 and Raf in focus formation assays. Taken together, these results indicated that UTD2 exerted multiple effects on the actin cytoskeleton and signaling pathways associated with Rac1. This study provided novel insights into the molecular mechanism of the antineoplastic and antimetastatic activities of epothilones. Our findings also suggest that the signaling pathways regulated by Rac1 may be evaluated as biomarkers for the response to therapy in clinical trials of epothilones. -
Calcium수송기전에 미치는 Carbachol의 영향
이종화(Jong Hwa Lee) 대한약리학회 대한약리학잡지 10 Pages
대한약리학회 대한약리학잡지 1995, 제 31권 제 3호 10 355-364 (10 pages)
Calcium수송에 대한 기전을 추구하기위하여, carbachol을 사용하여 ml muscarinic receptor-transfected RBL-2H3 cell-line에서 다음과 같은 실험결과를 얻었기에 이에 보고한다. 1) Carbachol의 투여로 이들 cell-line에서 Ca2+ influx가 농도에 따라 증가하였고, hexosaminidase 분비양도 의의있게 증가하였다. 2) Atropine 투여로 Carbachol의 상승작용이 의의있게 억제되었다. 3) 수종의 금속양이온을 투여하여 carbachol의 Ca2+수송에 대한 영향을 관찰한 바, 이들 금속이온들은 Ca2+의 influx를 의의있게 억제하였다. 4) PMA(20 nM)... -
항암활성 수종생약의 B16-Fo와 A549 암세포에 대한 항전이 효과( I )
김성훈, 유시용, Kim. Sung-Hoon, Ryu. Shi-Yong 대한한의학회 大韓韓醫學會誌 21 Pages
대한한의학회 大韓韓醫學會誌 1996, Vol.17 No.1 111-131 (21 pages)
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항혈관 1호의 항전이에 관한 연구
손창규, 조종관, 이승호, Son. Chang Kyu, Cho. Chong Kwan, Lee. Seung ho 대한동의생리학회 동의생리병리학회지 8 Pages
대한동의생리학회 동의생리병리학회지 2002, Vol.16 No.1 133-140 (8 pages)
