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본문검색 결과만 보기
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Regulation of matrix metalloproteinase-9 protein expression by 1α, 25-(OH)2D3 during osteoclast differentiation
Jian-Hong Gu, Xi-Shuai Tong, Guo-Hong Chen, Xue-Zhong Liu, Jian-Chun Bian*, Yan Yuan, Zong-Ping Liu* 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 1호 15 133-140 (8 pages)
of matrix metalloproteinase-9 (MMP-9) protein expression during osteoclast formation and differentiation, receptor activator of nuclear factor κB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) were administered to induce the differentiation of RAW264.7 cells into osteoclasts. The cells were incubated with different concentrations of 1α,25-(OH)2D3 during culturing, and cell proliferation was measured using the methylthiazol tetrazolium method. Osteoclast formation was confirmed... -
Thrombin-induced Migration and Matrix Metalloproteinase-9 Expression Are Regulated by MAPK and PI3K Pathways in C6 Glioma Cells
JiyoungKim, Jae-WonLee, Song-InKim, Yong-JoonChoi, Won-KiLee, Myung-JaJeong, Sang-HoonCha, HeeJaeLee, WanjooChun, Sung-SooKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.4 4 211-216 (6 pages)
Glioblastoma multiforme is one of the most common and aggressive tumors in central nervous system. It often possesses characteristic necrotic lesions with hemorrhages, which increase the chances of exposure to thrombin. Thrombin has been known as a regulator of MMP-9 expression and cancer cell migration. However, the effects of thrombin on glioma cells have not been clearly understood. In the present study, influences of thrombin on glioma cell migration were examined using Boyden chamber... -
Effects of (-)-Epigallocatechin-3-gallate on Brain Infarction and the Activity Change of Matrix Metalloproteinase-9 Induced by Middle Cerebral Artery Occlusion in Mice
YongRiQian, JiHyunKook, ShinaeHwang, DoKyungKim, Jong-KeunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.3 2 85-88 (4 pages)
volume in focal brain ischemia and inhibit MMP-9 activity. To delineate the relationship between the anti-ischemic action and the MMP-9-inhibiting action of EGCG, we investigated the effect of EGCG on brain infarction and the activity of matrix metalloproteinase-9 induced by permanent middle cerebral artery occlusion (pMCAO) in ICR mice. EGCG (40 mg/kg, i.p. 15∼30 min prior to MCAO) significantly decreased infarction volume at 24 hr after MCAO. GM 6001 (50 mg/kg, i.p. 15∼30 min prior to MCAO),... -
Dieckol Inhibits 12-O-tetradecanoylphorbol-13-acetate-induced SK-Hep1 Human Hepatoma Cell Motility through Suppression of Matrix Metalloproteinase-9 Activity
Oh. Sang-Muk, Park. Chang-Gyo, Kang. Joo-Hee, Kim. Eun-Jung, Chee. Hee-Youn, Lee. Bong-Ho, Lee. Kyung-Bok 한국응용생명화학회 Journal of the Korean Society for Applied Biological Chemistry 6 Pages
한국응용생명화학회 Journal of the Korean Society for Applied Biological Chemistry 2011, Vol.54 No.3 376-381 (6 pages)
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Suppressive Effects of Anthriscus sylvestris Constituents on the Expression and Production of Matrix Metalloproteinase-9 Using Luciferase Transfected Raw 264.7 Cell Based Assay System
Lim. Hye-Sun, Oh. Sei-Ryang, Lee. Ho-Jae, Chin. Young-Won, Ahn. Kyung-Seop, Sok. Dai-Eun, Lee. Hyeong-Kyu 한국응용생명화학회 Journal of applied biological chemistry 6 Pages
한국응용생명화학회 Journal of applied biological chemistry 2009, Vol.52 No.6 620-625 (6 pages)
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Chemokine Lkn-1/CCL15 enhances matrix metalloproteinase-9 release from human macrophages and macrophage-derived foam cells
Kwon. Sang-Hee, Ju. Seong-A, Kang. Ji-Hye, Kim. Chu-Sook, Yoo. Hyeon-Mi, Yu. Ri-Na 한국영양학회 Nutrition research and practice 4 Pages
한국영양학회 Nutrition research and practice 2008, Vol.2 No.2 134-137 (4 pages)
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Role of Decursin in TNF-${alpha}$-stimulated Migration, Invasion, and Matrix Metalloproteinase-9 Induction in Vascular Smooth Muscle Cells
Park. Sung-Suk, Kim. Wun-Jae, Moon. Sung-Kwon 한국식품과학회 Food science and biotechnology 6 Pages
한국식품과학회 Food science and biotechnology 2011, Vol.20 No.4 913-918 (6 pages)
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Sulfolaphane이 lipopolysaccharide (LPS)에 의해 유도된 matrix metalloproteinase-9 (MMP-9) 발현에 미치는 영향
이정태, 우경진, 권택규, Lee. Jung-Tae, Woo. Kyung-Jin, Kwon. Taeg-Kyu 한국생명과학회 생명과학회지 6 Pages
한국생명과학회 생명과학회지 2010, Vol.20 No.2 275-280 (6 pages)
Sulforaphane은 십자가화 채소에 존재하는 화합물로 항염증, 항암 및 신생혈관 생성의 억제 효과가 알려짐으로써 최근 많은 연구가 활발히 이루어지고 있으나, LPS에 의한 MMP-9 활성 조절에 대한 연구는 매우 미흡한 편이다. 따라서 본 연구에서 sulforaphane이 LPS 유도에 의한 MMP-9 활성에 미치는 영향에 대해서 조사해 보았다. Raw 264.7 세포에 sulforaphane을 전처리 한 후 LPS를 처리하여 gelatin zymography를 실시해 본 결과, LPS에 의해 유도된 MMP-9 활성 증가가 sulforaphane 농도 의존적으로 감소됨을 확인 하였다. 또한... -
Up-regulation of Matrix Metalloproteinase-9 in Smooth Muscle Cell Undergoing Death
이경아, 김선미, 김관회, Lee. Kyeong-Ah, Kim. Sun-Mi, Kim. Koan-Hoi 한국생명과학회 생명과학회지 6 Pages
한국생명과학회 생명과학회지 2006, Vol.16 No.7 1229-1234 (6 pages)
배지에 tetracycline이 없으면 사멸하는 평활근세포 (FADD-SMC)를 이용하여 metalloproteinase (MMP)와 사멸세포의 상관관계를 조사하였다. FADD-SMC를 tetracycline이 없는 배지에서 배양하는 경우 핵이 조각으로 잘라졌고 인산화한 p38과 ERK가 증가하고 MMP-9의 발현과 활성이 증가한 반면, cyclin D와 cyclin D의 발현은 감소하였다. 그리고 죽는 FADD-SMC에서 MMP-9의 발현은 immunofluorescen로 재확인하였다. MMP-9의 증가는 MAPK 억제제인 PD098059와 p38 MAPK 억제제인 SB203S80에 의하여 감소하였다. 그리고 MMP 억제제인...
