오리의 유일한 피지샘인 uropygial gland에서의 NADPH 생성경로를 간과 비교하여 조사하였다. 간에서는 이제까지 연구된 바와 같이 pentose phosphate pathway와 pyruvate-malate cycle이 서로 비슷한 활성도로서 NADPH를 생성함이 나타났으나 uropygial gland에서는 pentose phosphate pathway가 pyruvate-malate cycle보다 그 활성도에 있어서 거의 5배 이상 높았으며 특히 이 gland의 glucose-6-phosphate dehydrogenase는 malic enzyme 보다 약 6배 정도 높은 활성도를 지니고 있음이 밝혀졌다. 이상의 결과로 미루어 볼때 uropygial gland에서의 NADPH생성은 간의 경우에 비하여 주로 pentose phosphate pathway에 의존하고 있는 것으로 믿어진다.
It was examined about which enzyme system would play a major role for NADPH formation essential to fatty acid biosynthesis in the uropygial gland of Peking duck. By the comparison of each activity of $NADP^+$-specific enzymes in the both cell free extracts of the gland and the liver, the fact that pentose phosphate pathway was nearly five tines more active than pyruvate-malate cycle in the gland was revealed. Especially, the activity of glucose-6-phosphate dehydrogenase was about six times higher than that of malic enzyme. These results indicate that pentose phosphate pathway might be the major route for NADPH formation in the uropygial gland.
