Percutaneous cholecystostomy is regarded as a new method of treatment in patients with acute cholecystitis, especially patients with empyema who are considered unsuitable for cholecystectomy. In recent 2 years, authors performed percutaneous cholecystostomy for drainage purpose in 10 patients with poor surgical candidate. Under the guidance of real time ultrasound or fluoroscope, transhepatic access route for gallbladder intervention were chosen in all cases. successful decompression were obtained in 7 cases (70%; 6 patients with acute cholecystitis had decompression of gallbladder and 1 patient with common bile duct stone had biliary decompression. In three patient with cholecystitis, who had severe liver cirrhosis (N=1) or sepsis (N=2) as underlying condition, gallbladder drainage was not effective. Neither bile peritonitis nor hypotension occurred in any of these 10 cases. Percutaneous cholecystostomy has proved to be safe and effective treatment for patients with gallbladd r disease who are poor surgical candiate.