Partial splenic embolization (PSE) was performed in thirteen cirrhotics and two patients of idiopathic portal hypertension with hypersplenism using Gelfoam pieces suspended in an antibiotic solution. The patients were followed for 60 weeks after PSE, and decreased gradually but maintained within normal limit until 60 weeks after PSE. Platelet count increased immediately and normalized at the first week, and reached at the maximal value at the 4th week after PSE. And then platelet count decreased gradually but maintained within normal limit until 60 week after PSE. Hemoglobin value tended to increase gradually about 4 weeks after PSE without significant interval change initially. After PSE abdominal pain, fever, ascites and pleural effusion were observed ut were well tolerated, and there were no serious complications such as splenin abscess, subphrenic abscess, splenic rupture and so on. Consequently, PSE is thought to be an attractive therapeutic modality to physicians managi g patients with hypersplenism in portal hypertension not only because it is a nonsurgical procedure without serious complications but because it provides excellent results hematologically.