Background: Captopril is an angiotensin-converting enzyme inhibitor that has been widely used in treating hypertension. Cough has been recognized as a side effect, but has little attention in the pulmonary literature. Method: To emphasize that angiotensin-converting enzyme inhibitor should be considered among possible etiology of chronic cough, we report clinical investigation about 15 patients with captopril-induced cough. Results: The age range of the 15 patients was 48 to 82 years (mean 58.5 years). There were 5 men and 10 women. Captopril dosage in patients with cough was 25-75 mg (mean 43.3 mg). Onset of cough after starting a captopril ranged from 5 days to 180 days (mean 55.2 days), and cessation of cough after discontinuation of the drug was as early as one day and no longer than 7 days. Conclusion: It is necessary to recognize that chronic cough is not uncommon with the use of captopril.