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심근병에서 $^{123}I-MIBG$ 영상을 이용한 교감신경기능의 평가
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  • 심근병에서 $^{123}I-MIBG$ 영상을 이용한 교감신경기능의 평가
저자명
김선정,이종두,이도연,박창윤,함진경,정남식,조승연,이성숙,김용수,Kim. Sun-Jung,Lee. Jong-Doo,Lee. Do-Yun,Park. Chang-Yoon,Ham. Jin-Kyung,Chung. Nam-Sik,Cho.
간행물명
大韓核醫學會誌
권/호정보
1993년|27권 2호|pp.195-202 (8 pages)
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대한핵의학회
파일정보
정기간행물|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

$^{123}Iodine$-metaiodobenzylguanidine (MIBG) which is a norepinephrine analogue, can be used to evaluate the sympathetic innervation of the heart. In this study, cardiac imaging with $^{123}I-MIBG$ was performed in patients with 9 dilated cardiomyopathy, 2 ischemic cardiomyopathy and 1 acute myocardial infarction to evaluate the sympathetic nervous function. $^{123}I-MIBG$ imaging showed multifocal defects (8), diffuse defect (2), near non-visualization (2). The defects of MIBG scans were found to be larger and more severe on 4 hours image than 30 minutes. Heart to lung, heart to mediastinum ratios were decreased at 4 hours than those at 30 minutes. Measured LVEF values were not correlated with the severity of MIBG uptake. $^{99m}Tc-MIBI$ imaging was also performed in all patients to find the relationship with $^{123}I-MIBG$ scan. $^{99m}Tc-MIBI$ scan showed multifocal defects in 9 patients, diffuse defects in 1 patient and no defect in 2 patients. The defects are similar in size, severity and extent, but more larger and severe on $^{123}I-MIBG$ imaging. Therefore, cardiac $^{123}I-MIBG$ imaging is a useful method to evaluate the sympathetic nervous function in cardiomyopathy.