Improving quality of life can be achieved by rehabilitating one socially and restoring their sexual life. Holistic care for persons with disabilities means the rehabilitation nurse intervenes when problems of sexual function are discovered, observed, or expressed. However, most people with chronic illnesses and disabilities must confront prevalent myths about their sexual nature and abilities. These myths often have their basis in the notion, common in our society, that the only people who are sexual are those who are young and beautiful. People who are obese, old, or do not conform to current standards of sexual attractiveness are usually deemed as asexual or undesirable. These narrow sterotypes have been particularly damaging to physically or mentally disabled people. People with chronic illnesses and disabilities often have special needs regarding their sexual behavior. Most of us will confront chronic illness or disability in our own lives to some degree. In addition, illnss or disability can occur at any age. In this study, I discuss some of the special needs of people with chronic illnesses and disabilities and the methods of coping with those needs. I also discuss some of the sexual concerns that people with chronic illnesses and disabilities have in common, and the assessment of sexual function and nursing strategies through literature review.