The factors that affect the nurse-patient interaction were identified. Sixty-six nurses participated in the cross-sectional survey. Based upon the literature, the factors were classified into 4 categories : the patient, the nurse, the family caregiver, and the situational factors. The data were collected with the open-and closed-ended questionnaire developed by researchers. In the closed-ended questionnaire, the significant factors differentiating the best-liked from the least-liked caring situation were found in all factors except the nurse factors. None of the nurse factors was found to be significant. In patient factors, the physically attractive stereotype was found to affect patient-nurse interaction. As expected, family caregiver factors were found to affect the nurse-patient interaction. The content analysis was done to identify the specific factors affecting nurse-patient interaction. In both of the best-liked and the least-liked caring situations, the patient factors were the most contributing causes as likely as 68.51% and 66.45%, respectively. Some factors that nurses perceived as causes for the best-liked and the least-liked to care were presented. In conclusion, these results show that nurses are influenced by stereotypes in caring patients. So, some programs to increase awareness of the biases of nurses are included in in-service education. Also the incentives to encourage nurses are needed.