The estimation of fatigue life at the design stage is very important in order to arrive at feasible and cost effective solutions considering the total lifetime of the structure and machinery compo-nents. In this study the practical procedure of prediction of fatigue life by use of cumulative damage factors based on Miner-Palmgren hypothesis and probability density function is shown with a $135,000m^3$ LNG tank being used as an example. In particular the parameters of Weibull distribution taht determine the stress spectrum are dis-cussed. At the end some of uncertainties associated with fatigue life prediction are discussed. The main results obtained from this study are as follows: 1. The practical procedure of prediction of fatigue life by use of cumulative damage factors expressed in combination of probability density function and S-N data is proposed. 2. The calculated fatigue life is influenced by the shape parameter and stress block. The conser-vative fatigue design can be achieved when using higher value of shape parameter and the stress blocks divded into more stress blocks.