This study was peformed to elucidate the effects of antler, red ginseng, safflower seed, ipriflavone and estrogen on ovariectomized rats. The rats were fed with Ca and P deficient diet for five weeks to induce osteoporosis. After this period, these animals were fed with normal for and treated every other day with antler(600mg/kg, PO), red ginseng(200mg/kg, PO), safflower(200mg/kg, PO), ipriflavone(80mg/kg, PO) and estrogene(400$mu extrm{g}$/kg, IM) for S weeks. During the treatment, the rats were examined for body, organ, femur and femur ash weights. And electron-microscopical examinations were also performed on femora. The results are summarized as follows : 1. The body weights of the antler, red ginseng, safflower, ipriflavone and estrogen-treated groups after five weeks of treatment, were 303.0$pm$3.0g, 273.3$pm$4.4g, 288.3$pm$5.1g, 300.5$pm$5.2g, 320.5$pm$4.2g, respectively. They, except the red ginseng-treated group, were significantly higher than 278.4$pm$2.7g of normal control group(P<0.05). And the body weight of non-treatment group was 29it.2$pm$5.5g which was higher than that of control group, too. 2. The weights of left femur after five weeks of treatment were showed 0.83$pm$0.2g by antler, 0.89$pm$0.2g by red ginseng, 0.87$pm$0.2g by safflower 0.83$pm$0.1g by ipriflavone and 0.78$pm$0.1g by estrogen-treated group. They were a little lower than 0.97$pm$0.1g of normal control group. Non-treatment group showed 0.83$pm$0.1g which was lower than that of control group but not significant. 3. The weights of ashed left femora after five weeks of treatment were showed 0.36$pm$0.01g by antler, 0.40$pm$0.01g by red ginseng, 0.41$pm$0.01g by safflower, 0.36$pm$0.01g by ipriflavone and 0.35$pm$0.01g by estrogen-treated group. Those results were significantly lower than 0.43$pm$0.01g of normal control group. And non-treatment group showed 0.29$pm$0.01g of femoral ash which was significantly lower than that showed by control group(p<0.05). 4. The femoral Ca contents of the antler, red ginseng, safflower, ipriflavone and estrogen-treated rats were 19.6$pm$0.7%, 17.8$pm$1.1%, 18.8$pm$0.9%, 18.0$pm$1.1%, 15.3$pm$1.1%, respectively, after five weeks of treatment. The femoral Ca contents of antler and safflower-treated groups were higher than that of control group which showed 18.2$pm$0.9% of Ca The non-treatment group, showing 15.3$pm$0.7%, had significantly lower content of Ca than normal group(p<0.05). 5. The weights of liver, spleen, and kidney in the osteoporosis-induced rats during the treatment with antler, red ginseng, safflower, jpriflavone and estrogen showed not significant changes. 6. The connections among the trabeculae of control group were maintained well, showing no bone loss. However, the connections among the trabeculae of non-treatment group were thinner than those of control group and were almost disconnected and the lacunae were found to be broadened. Antler and safflower-treated group showed only slight changes. The recovery rates were prominent in antler, safflower, estrogen-treated groups but they were insignificant in red ginseng and ipriflavone-treated groups.