This study was performed to elucidate the effects of antler, red ginseng, safflower seed, ipriflavone and estrogen on ovariectomized rats. The rats were fed with Ca and P deficient diet for five weeks to induce osteoporosis. After this period, these animals were fed with normal feed and treated every other day with antler(600 mg/kg, p.o), red ginseng(200 mg/kg, p.o), safflower(200 mg/kg, p.o), ipriflavone(80 mg/kg, p.o) and estrogene(400$mu extrm{g}$/kg, i.m) for 5 weeks. During the treatment, the rats were examined for serum concentrations of estradiol, calcitonin, Ca, p and alkaline phosphatase(ALP) activities. The results are summarized as follows 1. The levels of serum 17 $eta$-estradiol after five weeks of treatment were showed 39.6$pm$3.0 pg/ml by antler, 33.2$pm$2.5pg/ml by red ginseng, 34.9$pm$2.4pg/ml by safflower, 28.1$pm$3.1 pg/ml by ipriflavone and 40.6$pm$3.0pg/ml by estrogen-treated group. They were lower than 50.8$pm$3.1pg/ml of normal control group which had not received ovariectomy. They, however, were significantly higher than 26.8$pm$1.8pg/ml of ovariectomized non-treatment group(p<0.05). 2. The levels of serum calcitonin after five weeks of treatment were showed 0.60$pm$0.02 ng/ml by antler, 0.55$pm$0.04ng/ml by red ginseng, 0.59$pm$0.02ng/ml by safflower, 0.56$pm$0.04ng/ml by ipriflavone and 0.62$pm$0.02ng/ml by estrogen-treated group. They were lower than 0.67$pm$0.03pg/ml of normal control group. However, they were significantly higher than 0.45$pm$0.05ng/ml of ovariectomized non-treatment group(p<0.05). 3. The levels of serum Ca of the rats after five weeks of treatment with antler, red ginseng, safflower, ipriflavone and estrogen were 23.51$pm$2.19$mu extrm{g}$/$mell$, 25.22$pm$3.44$mu extrm{g}$/$mell$, 23.20$pm$0.02$mu extrm{g}$/$mell$, 24.76$pm$3.57$mu extrm{g}$/$mell$, 23.07$pm$3.66$mu extrm{g}$/$mell$, respectively. They were a bit higher than 21.43$pm$2.22$mu extrm{g}$/$mell$ of normal control group. And non-treatment group showed 26.12$pm$0.29$mu extrm{g}$/$mell$ which was significantly higher than that of control group(P<0.05). 4. The serum P concentraions after five weeks of treatment were showed 12.11$pm$2.14$mu extrm{g}$/$mell$ by antler, 13.18$pm$1.64u91m4 by red ginseng, 12.67 $pm$2.31$mu extrm{g}$/$mell$ by safflower, 12.38$pm$2.07$mu extrm{g}$/$mell$ by ipriflavone, 11.86$pm$1.93$mu extrm{g}$/$mell$ by estrogen-treated group. They were a bit higher than 11.29$pm$1.23$mu extrm{g}$/$mell$ of normal control group. And non-treatment group showed 13.42$pm$1.87$mu extrm{g}$/$mell$ which was higher than that of control group but not significant. 5. The levels of serum ALP after five weeks of treatment were showed 164.8$pm$3.8IU/ml by antler, 277.7$pm$4.8IU/ml by red ginseng, 288.5$pm$4.5IU/ml by safflower, 214.7$pm$5.7IU/ml by ipriflavone and 159.4$pm$5.4IU/ml by estrogen-treated group. They were significantly higher than 144.1$pm$3.5IU/ml of normal control group(p<0.05). However, they were significantly lower than 336.9 $pm$12.7IU/ml of ovariectomized non-treatment group(p<0.05). Antler and safflower elevated serum estradiol and calcitonin, and decreased serum ALP significantly. Therefore they were thought to have therap..