This paper is concerned with a vehicle routing model to assist in scheduling palletized cargo pickup and delivery so called the pickup and delivery problem with advance requests in a 2-echelon supply-chain system. In this study vehicles is dispatched and routed so that each request is picked up or delivered at its original and to its destination. The model provides point-to-point transportations based on advance requests. The assignment algorithm is developed and designed for using with on-line computers and it immediately provides arrangements to be made at the time requested. This algorithm also provides the best scheduling solutions and alternatives for both to system operators and requesters. According to this algorithm, we developed computer programs and show the sample results.